Publications

2014

+ Lin, R.Z., Moreno-Luna, R., Li, D., Jaminet, S.C., Greene, A.K. & Melero-Martin, J.M. Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. Proc Natl Acad Sci U S A. Link

+ Lin, C.I., Merley, A., Sciuto, T.E., Li, D., Melero-Martin, J.M., Dvorak, A.M., Dvorak, H.F. & Jaminet, S.C. TM4SF1: a new vascular therapeutic target in cancer. Angiogenesis in press. PDF Supplement

+ Lin, C.I., Lau, C.Y., Li, D. & Jaminet, S.C. Nanopodia--thin, fragile membrane projections with roles in cell movement and intercellular interactions. Journal of visualized experiments : JoVE, e51320. PDF Reagents

+ Dharaneeswaran, H., Abid, M.R., Yuan, L., Dupuis, D., Beeler, D.L., Spokes, K., Janes, L., Sciuto, T., Kang, P.M., Jaminet, S.C., Dvorak, A., Grant, M.A., Regan, E. & Aird, W.C. FoxO1-Mediated Activation of Akt Plays a Critical Role in Vascular Homeostasis. Circ Res. Link

2013

+ Yuan, L., Janes, L., Beeler, D., Spokes, K.C., Smith, J., Li, D., Jaminet, S.C., Oettgen, P. & Aird, W.C. Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium. Blood 121, 4404-4412. Link

+ Siegenthaler, J.A., Choe, Y., Patterson, K.P., Hsieh, I., Li, D., Jaminet, S.C., Daneman, R., Kume, T., Huang, E.J. & Pleasure, S.J. Foxc1 is required by pericytes during fetal brain angiogenesis. Biology open 2, 647-659. Link

+ Lin, R.Z., Moreno-Luna, R., Munoz-Hernandez, R., Li, D., Jaminet, S.C., Greene, A.K. & Melero-Martin, J.M. Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential. Angiogenesis 16, 735-744. Link

2011

+ Zukauskas, A., Merley, A., Li, D., Ang, L.H., Sciuto, T.E., Salman, S., Dvorak, A.M., Dvorak, H.F. & Jaminet, S.C. TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration. Angiogenesis 14, 345-354. PDF Supplement

+ Yuan, L., Sacharidou, A., Stratman, A.N., Le Bras, A., Zwiers, P.J., Spokes, K., Bhasin, M., Shih, S.C., Nagy, J.A., Molema, G., Aird, W.C., Davis, G.E. & Oettgen, P. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Blood 118, 1145-1153. Link

+ Sitohy, B., Nagy, J.A., Jaminet, S.C. & Dvorak, H.F. Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy. Cancer Res 71, 7021-7028. Link

+ Lin, R.Z., Dreyzin, A., Aamodt, K., Li, D., Jaminet, S.C., Dudley, A.C. & Melero-Martin, J.M. Induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release. Blood 118, 5420-5428. Link

+ Fu, Y., Nagy, J.A., Brown, L.F., Shih, S.C., Johnson, P.Y., Chan, C.K., Dvorak, H.F. & Wight, T.N. Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis. J Histochem Cytochem 59, 463-473. Link

2010

+ Wada, Y., Li, D., Merley, A., Zukauskas, A., Aird, W.C., Dvorak, H.F. & Shih, S.C. A multi-gene transcriptional profiling approach to the discovery of cell signature markers. Cytotechnology 63, 25-33. PDF

+ Shapiro, N.I., Khankin, E.V., Van Meurs, M., Shih, S.C., Lu, S., Yano, M., Castro, P.R., Maratos-Flier, E., Parikh, S.M., Karumanchi, S.A. & Yano, K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol 185, 517-524. Link

+ Nucera, C., Muzzi, P., Tiveron, C., Farsetti, A., La Regina, F., Foglio, B., Shih, S.C., Moretti, F., Della Pietra, L., Mancini, F., Sacchi, A., Trimarchi, F., Vercelli, A. & Pontecorvi, A. Maternal thyroid hormones are transcriptionally active during embryo-foetal development: results from a novel transgenic mouse model. J Cell Mol Med 14, 2417-2435. Link

+ Nagy, J.A., Chang, S.H., Shih, S.C., Dvorak, A.M. & Dvorak, H.F. Heterogeneity of the tumor vasculature. Semin Thromb Hemost 36, 321-331. Link

+ Matsuda, K., Ohga, N., Hida, Y., Muraki, C., Tsuchiya, K., Kurosu, T., Akino, T., Shih, S.C., Totsuka, Y., Klagsbrun, M., Shindoh, M. & Hida, K. Isolated tumor endothelial cells maintain specific character during long-term culture. Biochem Biophys Res Commun 394, 947-954. Link

+ Ismail, N.S., Pravda, E.A., Li, D., Shih, S.C. & Dallabrida, S.M. Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells. J Invest Dermatol 130, 1307-1317. Link

+ Dudley, A.C., Udagawa, T., Melero-Martin, J.M., Shih, S.C., Curatolo, A., Moses, M.A. & Klagsbrun, M. Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. Blood 116, 3367-3371. Link

2009-2006

+ Shih, S.C., Zukauskas, A., Li, D., Liu, G., Ang, L.H., Nagy, J.A., Brown, L.F. & Dvorak, H.F. The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res 69, 3272-3277 (2009). PDF Supplement

+ Shapiro, N.I., Yano, K., Sorasaki, M., Fischer, C., Shih, S.C. & Aird, W.C. Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis. J Vasc Res 46, 495-502 (2009). Link

+ Liu, J., Kanki, Y., Okada, Y., Jin, E., Yano, K., Shih, S.C., Minami, T. & Aird, W.C. A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice. J Thromb Haemost 7, 1384-1392 (2009). Link

+ Jin, E., Liu, J., Suehiro, J.I., Yuan, L., Okada, Y., Nikolova-Krstevski, V., Yano, K., Janes, L., Beeler, D., Spokes, K.C., Li, D., Regan, E., Shih, S.C., Oettgen, P., Minami, T. & Aird, W.C. Differential roles for ETS, CREB and EGR binding sites in mediating VEGF receptor 1 expression in vivo. Blood (2009). Link

+ English, S.B., Shih, S.C., Ramoni, M.F., Smith, L.E. & Butte, A.J. Use of Bayesian networks to probabilistically model and improve the likelihood of validation of microarray findings by RT-PCR. J Biomed Inform 42, 287-295 (2009). Link

+ Chang, S.H., Kanasaki, K., Gocheva, V., Blum, G., Harper, J., Moses, M.A., Shih, S.C., Nagy, J.A., Joyce, J., Bogyo, M., Kalluri, R. & Dvorak, H.F. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res 69, 4537-4544 (2009). Link

+ Yano, K., Okada, Y., Beldi, G., Shih, S.C., Bodyak, N., Okada, H., Kang, P.M., Luscinskas, W., Robson, S.C., Carmeliet, P., Karumanchi, S.A. & Aird, W.C. Elevated levels of placental growth factor represent an adaptive host response in sepsis. J Exp Med 205, 2623-2631 (2008). Link

+ Dudley, A.C., Shih, S.C., Cliffe, A.R., Hida, K. & Klagsbrun, M. Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine. Br J Cancer 99, 118-125 (2008). Link

+ Dudley, A.C., Khan, Z.A., Shih, S.C., Kang, S.Y., Zwaans, B.M., Bischoff, J. & Klagsbrun, M. Calcification of multipotent prostate tumor endothelium. Cancer Cell 14, 201-211 (2008). Link

+ Abid, M.R., Nadeau, R.J., Spokes, K.C., Minami, T., Li, D., Shih, S.C. & Aird, W.C. Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells. Arterioscler Thromb Vasc Biol 28, 2042-2048(2008). Link

+ Okada, Y., Yano, K., Jin, E., Funahashi, N., Kitayama, M., Doi, T., Spokes, K., Beeler, D.L., Shih, S.C., Okada, H., Danilov, T.A., Maynard, E., Minami, T., Oettgen, P. & Aird, W.C. A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium. Circ Res 100, 1712-1722(2007). Link

+ Abid, M.R., Spokes, K.C., Shih, S.C. & Aird, W.C. NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways. J Biol Chem 282, 35373-35385(2007). Link

+ Yano, K., Liaw, P.C., Mullington, J.M., Shih, S.C., Okada, H., Bodyak, N., Kang, P.M., Toltl, L., Belikoff, B., Buras, J., Simms, B.T., Mizgerd, J.P., Carmeliet, P., Karumanchi, S.A. & Aird, W.C. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med 203, 1447-1458 (2006). Link

+ Nagy, J.A., Feng, D., Vasile, E., Wong, W.H., Shih, S.C., Dvorak, A.M. & Dvorak, H.F. Permeability properties of tumor surrogate blood vessels induced by VEGF-A. Lab Invest 86, 767-780 (2006). Link

+ Abid, M.R., Yi, X., Yano, K., Shih, S.C. & Aird, W.C. Vascular endocan is preferentially expressed in tumor endothelium. Microvasc Res 72, 136-145 (2006). Link

+ Abid, M.R., Shih, S.C., Otu, H.H., Spokes, K.C., Okada, Y., Curiel, D.T., Minami, T. & Aird, W.C. A novel class of vegf-responsive genes that require forkhead activity for expression. J Biol Chem 281 35544-35553 (2006). Link

2005-2002

+ Wada, Y., Otu, H., Wu, S., Abid, M.R., Okada, H., Libermann, T., Kodama, T., Shih, S.C., Minami, T. & Aird, W.C. Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell. Faseb J 19, 1914-1916 (2005). Link

+ Shih, S.C. & Smith, L.E. Quantitative multi-gene transcriptional profiling using real-time PCR with a master template. Exp Mol Pathol 79, 14-22 (2005). PDF

+ Agarwal, A., Munoz-Najar, U., Klueh, U., Shih, S.C. & Claffey, K.P. N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer. Am J Pathol 164, 1683-1696 (2004). Link

+ Shih, S.C., Ju, M., Liu, N. & Smith, L.E. Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity. J Clin Invest 112, 50-57 (2003). PDF Commentary

+ Shih, S.C., Ju, M., Liu, N., Mo, J.R., Ney, J.J. & Smith, L.E. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Proc Natl Acad Sci U S A 100, 15859-15864 (2003). PDF

+ Dallabrida, S.M., Zurakowski, D., Shih, S.C., Smith, L.E., Folkman, J., Moulton, K.S. & Rupnick, Ú.A. Adipose Tissue Growth and Regression Are Regulated by Angiopoietin-1. Biochem Biophy Res Comm 311, 563-571 (2003). Link

+ Shih, S.C., Robinson, G.S., Perruzzi, P., Calvo, A., Desai, K., Green, J., Ali, I., Smith, L.E. & Senger, D. Molecular Profiling of Angiogenesis Markers. Am J Pathol 161, 35-41. (2002). PDF Commentary

+ Calvo, A., Yokoyama, Y., Smith, L.E., Ali, I., Shih, S.C., Feldman, A.L., Libutti, S.K., Sundaram, R. & Green, J.E. Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatin. Int J Cancer 101, 224-234 (2002). Link

Before 2002

+ Shih, S.C. & Claffey, K.P. Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression. Growth Factors 19, 19-34 (2001). Link

+ Robinson, G.S., Ju, M., Shih, S.C., Xu, X., McMahon, G., Caldwell, R.B. & Smith, L.E. Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development. Faseb J 15, 1215-1217 (2001). Link

+ Claffey, K.P., Abrams, K., Shih, S.C., Brown, L.F., Mullen, A. & Keough, M. Fibroblast growth factor 2 activation of stromal cell vascular endothelial growth factor expression and angiogenesis. Lab Invest 81, 61-75 (2001). Link

+ Shih, S.C., Mullen, A., Abrams, K., Mukhopadhyay, D. & Claffey, K.P. Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells. J Biol Chem 274, 15407-15414 (1999). PDF

+ Shih, S.C. & Claffey, K.P. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. J Biol Chem 274, 1359-1365 (1999). PDF

+ Shih, S.C. & Claffey, K.P. Hypoxia-mediated regulation of gene expression in mammalian cells. Int J Exp Pathol 79, 347-357 (1998).Link

+ Claffey, K.P., Shih, S.C., Mullen, A., Dziennis, S., Cusick, J.L., Abrams, K.R., Lee, S.W. & Detmar, M. Identification of a human VPF/VEGF 3' untranslated region mediating hypoxia-induced mRNA stability. Mol Biol Cell 9, 469-481 (1998). Link

+ Shih, S.C. &Stutman, O. Cell cycle-dependent tumor necrosis factor apoptosis. Cancer Res 56, 1591-1598 (1996). Link

+ Shih, S.C. &Hsieh, J.H. Development of recombinant hepatitis B vaccine process. Proceedings of National Science Council, p285-295. (1988) ====check content. Link

+ Hsieh, J.H., Shih, K.Y., Kung, H.F., Ming, S., Lee, L.Y., Shih, S.C., Lee, S.Y., Chow, T.Y., Choo, K.B., Feng, T.Y. &Kou, T.T. Controlled fed-batch fermentation of recombinant Saccharomyces cerevisiae to produce hepatitis B surface antigen. Biotechnology and Bioengineering 32, 334-340. (1988). Link

+ Hsieh, J.H., Shih, S.C., Kung, H.F., Chang, C.C., Ming, S., Lin, H.M., Chen, W.C., Lee, L.Y., Wen, S.C., Shih, K.Y., Chang, T.H., Chen, K.C., Liu, S.T., Jeng, S.T., M., J.H., Lo, S.J., Choo, K.B., Chow, T.Y., Feng, T.Y., Kou, T.T., Pai, S.H., Lee, T.C., Wu, Y.H., Wu, J.L., Lin, J.Y., Chang, W.T.H. &Tien, W.C.Development of recombinant hepatitis B vaccine process. The 1987 Chinese American Academic and Professional Convention, Houston, Texas (1987). ====check content Link

+ Hsieh, J.H., Shih, K.Y., Kung, H.F., Ming, S., Lee, L.Y., Meng, M.H., Chang, C.C., Lin, H.M., Shih, S.C. & Lee, S.Y. High expression and production of hepatitis B surface antigen by recombinant Saccharomyces cerevisiae. CIVhE-AIChE Symposium on modern chemical engineering technology, 171-178. (1986). Link