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Welcome to the Lab of Shou-Ching Jaminet, Ph.D.

The home of TM4SF1 (Transmembrane-4-L-six-family)

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Shou-Ching Jaminet


Beth Israel Deaconess Medical Center

Harvard Medical School

Director, Multi-Gene Transcriptional Profiling Core

National Taiwan University (BS,MS)

Newcastle University, Australia (PhD)

I am a vascular biologist specializing in the study of tumor angiogenesis. I base much of my research on the view that the quantity of transcribed mRNA is the best indicator of a gene’s biological significance, and that multi-gene profiles showing per-cell quantities of mRNAs provide an informative window into the state of molecular networks.

To implement such a transcriptome-based research strategy, my lab developed Multi- Gene Transcriptional Profiling (MGTP), a method for efficiently and precisely measuring mRNA copy numbers per cell mRNA copy numbers per cell of multi-gene panels. Through MGTP, my group identified TM4SF1 as a new endothelial cell biomarker and a novel anti-angiogenic therapeutic target.

Before my group showed that TM4SF1 is an essential regulator of endothelial cell movement and proliferation, TM4SF1 was known only as a tumor cell antigen of tetraspanin topology; only 53 publications mentioning TM4SF1 had appeared through 2005.

We have now shown that: