Welcome to the Lab of Shou-Ching Jaminet, Ph.D.
The home of TM4SF1 (Transmembrane-4-L-six-family)
Beth Israel Deaconess Medical Center
Harvard Medical School
Director, Multi-Gene Transcriptional Profiling Core
National Taiwan University (BS,MS)
Newcastle University, Australia (PhD)
I am a vascular biologist specializing in the study of tumor angiogenesis.
I base much of my research on the view that the quantity of transcribed mRNA is the
best indicator of a gene’s biological significance, and that multi-gene profiles
showing per-cell quantities of mRNAs provide an informative window into the state of
To implement such a transcriptome-based research strategy, my lab developed Multi-
Gene Transcriptional Profiling (MGTP), a method for efficiently and precisely
measuring mRNA copy numbers per cell mRNA copy numbers per cell of multi-gene
panels. Through MGTP, my group identified TM4SF1 as a new endothelial cell
biomarker and a novel anti-angiogenic therapeutic target.
Before my group showed that TM4SF1 is an essential regulator of endothelial cell
movement and proliferation, TM4SF1 was known only as a tumor cell antigen of
tetraspanin topology; only 53 publications mentioning TM4SF1 had appeared
We have now shown that: